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Foundations of Protein Folding and Energy Landscapes

Welcome: Proteins as Dynamic Molecular Machines

The Protein Energy Landscape and Levinthal's Paradox

Quiz: Folding Fundamentals

Thermodynamics and Kinetics of Folding

Free Energy, Enthalpy and Entropy in Protein Stability

Folding Kinetics, Barriers and Denaturation

Quiz: Thermodynamics and Kinetics

Protein Folding Pathways and Dynamics

Folding Pathways, Intermediates and Transition States

Conformational Dynamics, Allostery and Function

Quiz: Folding Pathways and Dynamics

Molecular Chaperones and Proteostasis

Chaperone Systems: Hsp70, Hsp60 and Hsp90

Proteostasis Networks and Cellular Quality Control

Quiz: Chaperones and Proteostasis

Intrinsically Disordered Proteins

Disorder, Conformational Ensembles and Molecular Recognition

Biomolecular Condensates and Phase Separation

Quiz: Intrinsically Disordered Proteins

Protein Misfolding and Amyloid Diseases

From Misfolding to Oligomers and Amyloid Fibrils

Amyloidoses, Prions and Therapeutic Strategies

Quiz: Amyloid Pathology

X-Ray Crystallography

Crystallization, Diffraction and Bragg's Law

Phasing, Electron Density and Model Validation

Quiz: X-Ray Crystallography

NMR Spectroscopy

Nuclear Spin, Chemical Shifts and Multidimensional NMR

NMR Structure Determination and Protein Dynamics

Quiz: NMR Spectroscopy

Cryo-Electron Microscopy

Vitrification, Imaging and Single-Particle Analysis

Cryo-EM Resolution, Heterogeneity and Model Validation

Quiz: Cryo-Electron Microscopy

Integrative Structural Biophysics

Choosing Between X-Ray, NMR and Cryo-EM

Integrative Case Study: From Folding Defect to Mechanism

Final Assessment: Structural Biophysics

An advanced course examining the thermodynamics, kinetics and dynamics of protein folding; molecular chaperones and proteostasis; intrinsically disordered proteins; amyloid pathology; and structural determination by X-ray crystallography, NMR spectroscopy and cryo-electron microscopy.

An advanced course in the physical principles of protein folding, conformational dynamics, proteostasis, amyloid pathology and modern structural determination.

Protein Folding, Dynamics, and Structural Biophysics

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