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Section 1: Foundations of Optical Brain Mapping

Why Task-Based Brain Mapping Matters

What Brain Activation Is — and Is Not

Neurovascular Coupling

Section 2: Measurement Principles and Modalities

fNIRS Principles

Wide-Field and Two-Photon Fluorescence

Intrinsic Optical and Hemodynamic Imaging Approaches

Section 3: Task Design and Behavioral Paradigms

Task Design and Behavioral Measurement

Naturalistic Tasks and Hyperscanning

Section 4: Confounds, Correction, and Data Analysis

Short-Separation and Superficial Physiology

Motion and Systemic Confounds

Preprocessing and Statistical Modeling

Functional Connectivity and Networks

Section 5: Interpretation, Evidence, and Translation

Clinical and Cognitive Applications

Evidence Ladder

Translation Barriers

Stakeholder Questions

Quiz

Quiz: Foundations of Brain Mapping

Quiz: Neurovascular Coupling and Activation

Quiz: fNIRS Measurement Principles

Quiz: Advanced Fluorescence Techniques

Quiz: Cognitive Task Design

Quiz: Physiological Confounds and Correction

Quiz: Preprocessing and Statistical Modeling

Quiz: Functional Connectivity and Hyperscanning

Quiz: Clinical Applications and Validity

Quiz: Translating Optical Neuroimaging

Survey/Feedback

Survey: Course Pace and Structure Evaluation

Survey: Comprehension of fNIRS Principles

Survey: Clarity of Neurovascular Concepts

Survey: Application of Task Design Strategies

Survey: Fluorescence Imaging Utility

Survey: Statistical Modeling Confidence

Survey: Relevance of Connectivity Modules

Survey: Translation Barriers Assessment

Survey: Stakeholder Communication Effectiveness

Survey: Overall Course Efficacy and Impact

Welcome to "Optical Imaging Approaches for Task-Based Brain Activation Mapping," a comprehensive online course designed for cognitive neuroscientists, clinical researchers, and biomedical engineers. As the demand for non-invasive, high-resolution brain mapping grows, optical neuroimaging techniques like functional near-infrared spectroscopy (fNIRS), two-photon fluorescence, and intrinsic optical imaging have emerged as powerful tools.

Welcome to "Optical Imaging Approaches for Task-Based Brain Activation Mapping," a comprehensive online course designed for cognitive neuroscientists, clinical researchers, and biomedical engineers. As the demand for non-invasive, high-resolution brain mapping grows, optical neuroimaging techniques like functional near-infrared spectroscopy (fNIRS), two-photon fluorescence, and intrinsic optical imaging have emerged as powerful tools. This course bridges the gap between fundamental biophotonics and applied cognitive research. You will explore the physiological mechanisms of neurovascular coupling, differentiate true neural activity from metabolic proxies, and master the physical principles behind cutting-edge optical modalities. Beyond the hardware, this program dives deep into experimental task design, from highly controlled block paradigms to unconstrained naturalistic hyperscanning. You will learn to tackle major analytical challenges, including motion artifacts, systemic physiological confounds, and short-separation channel regression, ensuring your data is both clean and reliable. Finally, we will guide you through the translation of these findings into clinical and neuroergonomic applications, equipping you with the evidence frameworks needed to communicate effectively with stakeholders. Whether you are looking to refine your preprocessing pipelines using General Linear Modeling (GLM) or seeking to understand the barriers to clinical translation, this course provides the rigorous, end-to-end training required to excel in modern optical brain mapping. Join us to unlock the full potential of translational biophotonics and elevate your neuroimaging research.

66. Optical Imaging Approaches for Task-Based Brain Activation Mapping

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            <p>The precise mapping of task-based brain activation remains a cornerstone of modern cognitive neuroscience, systems neurobiology, and clinical research. This course provides a comprehensive examination of optical imaging approaches, offering researchers, clinicians, and neuroimaging teams the theoretical and methodological frameworks necessary to investigate cortical hemodynamics and cellular activity. By exploring the physiological mechanisms of neurovascular coupling, participants will learn to differentiate underlying neural action potentials from metabolic proxies and regional cerebral blood flow. The curriculum systematically evaluates the physical principles and technical architectures of leading modalities, including functional near-infrared spectroscopy (fNIRS), wide-field and two-photon fluorescence, and intrinsic optical imaging, establishing a rigorous foundation for capturing high-resolution spatial and temporal data across diverse experimental settings.</p>

<p>Beyond foundational measurement principles, the successful deployment of optical neuroimaging requires meticulous experimental design and robust analytical pipelines. This program critically analyzes behavioral paradigms, ranging from highly constrained event-related and block designs to unconstrained naturalistic tasks and hyperscanning methodologies used in social neuroscience. Recognizing the inherent challenges of optical data collection, the course emphasizes advanced techniques for mitigating motion artifacts and systemic physiological confounds, utilizing short-separation channel regression, and implementing General Linear Modeling (GLM) for accurate signal extraction. Ultimately, the curriculum bridges the gap between raw data and clinical utility, equipping interdisciplinary professionals—from data scientists and human-factors researchers to funders and non-specialist stakeholders—with an evidence-based framework to interpret functional connectivity, overcome physical translation barriers, and effectively communicate scientific findings.</p>
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