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Foundations of Nucleotide Biochemistry

Welcome: Why Nucleotide Metabolism Matters

Nucleosides, Nucleotides and Nitrogenous Bases

Purines, Pyrimidines and the Pentose Sugar

Nucleotide Pools, Feedback and Metabolic Balance

Knowledge Check: Nucleotide Foundations

De Novo Purine Biosynthesis

The Purine Ring Is Built on Ribose

Atom Sources and Formation of IMP

Branch Pathways: IMP to AMP and GMP

Regulation of Purine Biosynthesis

Knowledge Check: Purine Synthesis

Purine Salvage, Degradation and Hyperuricemia

Purine Salvage Pathways

Purine Degradation to Uric Acid

Hyperuricemia and Gout

Inherited Purine Disorders and Therapeutic Targets

Knowledge Check: Purine Salvage and Gout

Pyrimidine Biosynthesis and Salvage

The Pyrimidine Ring Is Built Before Ribose Attachment

Regulation and the UMP-to-UTP Pathway

Thymidylate Synthesis and Folate Chemistry

Pyrimidine Salvage and Degradation

Knowledge Check: Pyrimidine Metabolism

Nucleotide Degradation and Clinical Biochemistry

Ribonucleotide Reduction and Deoxyribonucleotide Supply

Nucleotide Pool Imbalance and Genome Stability

Clinical Case: Interpreting Elevated Serum Urate

Knowledge Check: Nucleotide Supply

DNA Replication Mechanics

The Semiconservative Principle and Replication Origins

The Replisome: Helicase, Primase and Polymerases

Leading and Lagging Strand Synthesis

Proofreading, Primer Removal and Chromosome Ends

Knowledge Check: DNA Replication

Enzymatic DNA Repair Pathways

DNA Damage, Lesions and Repair Strategy

Base-Excision Repair

Nucleotide-Excision Repair

Mismatch Repair

Double-Strand Break Repair: Homologous Recombination and NHEJ

Knowledge Check: DNA Repair

Clinical Integration and Applied Biochemistry

Antimetabolites and Nucleotide Pathway Inhibition

Integrated Case: Linking Metabolism to Genome Maintenance

Final Assessment: Nucleotide Metabolism and DNA Biochemistry

Course Review: Connecting Pathways, Disease and DNA Integrity

An intermediate-level course exploring purine and pyrimidine metabolism, nucleotide degradation and associated disorders, DNA replication, and enzymatic DNA repair.

Explore how cells build, recycle and degrade purine and pyrimidine nucleotides, then follow the molecular machinery that copies and repairs DNA. This intermediate-level course connects biochemical pathways with inherited disease, hyperuricemia and therapeutic intervention.

Nucleotide Metabolism and Nucleic Acid Biochemistry

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