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Start here

The decision you're learning to make

The hierarchy within mechanism

A mechanism climbs its own ladder

Two mechanisms, one discipline

Maria's coenzyme Q10, and urolithin A

Why the evidence is thin

The funding asymmetry, and why that is not nothing

Apply it: grade the mechanism

Grade the mechanism (do it)

Check yourself

Knowledge check: place it on the ladder

Knowledge check: necessary or sufficient

Knowledge check: no trial exists

Knowledge check: grade the mixed claim

What you can now do, and where it goes

What you can now do

Take it with you

Your mechanism card

References

Segment 1.4 of Module 1, appraising mechanism: grade a mechanistic claim [M], the in-vitro-to-outcome ladder, the funding asymmetry, and the bridge to Module 2. Built direct with the scored interaction, recall checks, take-away, self-check and references.

Module 1 - Evidence & Appraisal (Segment 1.4: Appraising Mechanism)

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