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Course Orientation and Standards

Common and Not-So-Common Challenges in Genitourinary Pathology

Important Information Regarding CME

Disclosure of Relevant Financial Relationships

USCAP Luminaries in Pathology

Core Renal Tumor Classification and Diagnostic Frameworks

WHO Classification of Renal Tumours (5th Edition)

Changes in Terminology that Suggest Low Malignant Potential

Case-Based Diagnostic Challenges in Renal Tumors

Case 1

Differential Diagnosis and IHC Profiles

Case 2

Comparative Features: EVT vs. SDH-Deficient RCC

Case 3

Oncocytic Renal Neoplasia and Immunohistochemistry

Immunohistochemistry in Renal Tumors with Cytoplasmic Eosinophilia (Oncocytic)

IHC Profile Table

Summary

Hereditary Renal Cell Carcinoma Syndromes and Key Entities

Hereditary Renal Cell Carcinoma Syndromes

Renal Cell Carcinoma in Tuberous Sclerosis Complex (TSC)

Distribution by Histologic Subtypes

Tuberous Sclerosis–associated Renal Cell Carcinoma

Oncocytosis and Birt-Hogg-Dubé (BHD) Syndrome

Renal Tumors in Cases of Oncocytosis

Renal Parenchyma in Cases of Oncocytosis

BHD Syndrome Features

Additional Case-Based Challenges in Genitourinary Pathology

Case 4

IHC Findings

Follow-up Cases (Observations)

Lessons Learned

Penalty for Misdiagnosis

Recommended Antibody Panel

Case 5

Pseudocarcinomatous Urothelial Hyperplasia

Case 6

Pathologic Findings

Cystitis Cystica and Glandularis with Intestinal Metaplasia

Knowledge Checks and Course Evaluation

Quiz 1: WHO Renal Tumor Categories and Updates

Quiz 2: Terminology Suggesting Low Malignant Potential

Quiz 3: IHC-Based Differential Diagnosis (Case 1)

Quiz 4: EVT vs. SDH-Deficient RCC Comparison (Case 2)

Quiz 5: Oncocytic Renal Tumors and IHC Use

Quiz 6: Interpreting IHC Profile Tables

Quiz 7: Hereditary RCC Syndromes—Core Recognition

Quiz 8: Tuberous Sclerosis Complex–Associated RCC

Quiz 9: Oncocytosis and Birt-Hogg-Dubé (BHD) Syndrome

Quiz 10: Avoiding Pitfalls in IHC Panels and Misdiagnosis (Case 4)

Course Evaluation Survey

Stay current with the rapidly evolving landscape of renal tumor diagnostics. Mastering Renal Pathology: WHO Updates and Diagnostic Strategies is a concise, expert-led course designed for practicing pathologists and trainees who want to apply the 5th edition WHO classification with confidence at the microscope. Through a blend of core frameworks, case-based challenges, and targeted immunohistochemistry (IHC) strategy, you will sharpen your ability to classify renal neoplasms, avoid common pitfalls, and communicate clinically meaningful reports. The curriculum starts with orientation and standards, then moves into essential updates to renal tumor taxonomy, terminology indicating low malignant potential, and practical differential diagnoses. You will work through real-world cases (including oncocytic tumors, EVT and SDH-deficient RCC comparisons, and hereditary syndromes such as TSC and BHD) to build pattern recognition and select cost-effective antibody panels. Structured knowledge checks reinforce key takeaways on WHO categories, IHC profiles, and hereditary RCC syndromes. By the end, you will be equipped with a reproducible diagnostic approach that aligns with contemporary guidelines, reduces misclassification risk, and supports multidisciplinary decision-making. If you are ready to upgrade your renal pathology workflow—while earning CME and building confidence across challenging cases—this course is for you.

Mastering Renal Pathology: WHO Updates and Diagnostic Strategies

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            <p>The landscape of genitourinary pathology is undergoing a significant transformation, driven by the refined classifications and molecular insights presented in the WHO Classification of Renal Tumours (5th Edition). This course provides a comprehensive exploration of these updates, emphasizing the critical shift toward terminology that reflects low malignant potential and the nuances of modern diagnostic frameworks. Pathologists must navigate increasingly complex criteria to ensure accurate categorization, particularly as molecular characterization continues to redefine traditional morphologic boundaries. By examining the latest standards and orientation in the field, practitioners can better address both common and rare challenges encountered in daily clinical practice.</p>

<p>Beyond foundational classification, this curriculum utilizes a rigorous case-based methodology to dissect diagnostic pitfalls and refine immunohistochemical (IHC) strategies. Special attention is given to the differential diagnosis of oncocytic renal neoplasia, including the comparative features of Eosinophilic Vacuolated Tumor (EVT) and SDH-deficient Renal Cell Carcinoma (RCC). Furthermore, the course delves into the pathology of hereditary syndromes such as Tuberous Sclerosis Complex (TSC) and Birt-Hogg-Dubé (BHD) syndrome, providing pathologists with the tools to recognize syndromic associations through histologic patterns and specific IHC profiles. Through detailed analysis of recommended antibody panels and lessons learned from complex cases, this program aims to enhance diagnostic precision and mitigate the risks associated with misdiagnosis in renal and urothelial pathology.</p>
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