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Foundations of Lipid Biochemistry

Welcome to Lipid Metabolism and Membrane Biochemistry

Lipid classes, fatty acid structure and amphipathicity

Membrane composition, fluidity and asymmetry

Foundations knowledge check

Fatty Acid Catabolism and Beta-Oxidation

Mobilisation and activation of fatty acids

The carnitine shuttle and mitochondrial entry

The beta-oxidation spiral and energetic yield

Regulation, unsaturated fatty acids and organelle specialisation

Beta-oxidation knowledge check

Ketone Body Metabolism

Hepatic ketogenesis during fasting

Ketolysis and extrahepatic energy use

Physiological ketosis and diabetic ketoacidosis

Ketone metabolism knowledge check

De Novo Lipogenesis and Lipid Biosynthesis

Citrate export and acetyl-CoA supply

Acetyl-CoA carboxylase and fatty acid synthase

Elongation, desaturation and triacylglycerol synthesis

Lipogenesis knowledge check

Eicosanoid Biosynthesis and Lipid Signalling

Arachidonic acid release and cyclooxygenase pathway

Lipoxygenase pathways and leukotrienes

Clinical pharmacology of eicosanoids

Eicosanoid knowledge check

Cholesterol Metabolism and Lipoprotein Transport

Cholesterol biosynthesis and HMG-CoA reductase

Lipoproteins, cholesterol delivery and reverse transport

Cholesterol fate, bile acids and clinical dysregulation

Cholesterol knowledge check

Membrane Organisation and Lipid Rafts

Lipid rafts as dynamic membrane nanodomains

Methods for studying membrane microdomains

Membrane signalling and raft-associated proteins

Membrane organisation knowledge check

Transmembrane Lipid Transport and Kinetics

Transbilayer movement and lipid transport proteins

Intracellular lipid transfer and vesicular transport

Transport kinetics and experimental interpretation

Transmembrane transport knowledge check

Clinical Integration and Applied Lipid Biochemistry

Integrating lipid flux across fed, fasting and exercise states

Clinical case study: dyslipidaemia and fatty liver

Clinical case study: inherited lipid pathway defects

Integrated lipid metabolism final assessment

An advanced, mechanism-focused course on fatty acid oxidation, ketogenesis, lipogenesis, eicosanoid signalling, cholesterol homeostasis, membrane organisation and transmembrane lipid transport.

An advanced, mechanism-focused course exploring fatty acid oxidation, ketone metabolism, lipid synthesis, eicosanoid signalling, cholesterol homeostasis, membrane microdomains and transmembrane lipid movement.

Lipid Metabolism and Membrane Biochemistry

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